Role of Toll-like receptors in the pathogenesis of COVID-19.

Toll-like receptors (TLRs) play a crucial role in the immune response to COVID-19. These receptors recognize viral particles and trigger the innate immune system, leading to the release of pro-inflammatory cytokines and type 1 interferon. Multiple TLRs (2, 3, 4, 6, 7, 8, and 9) are potentially significant in COVID-19 infection. While TLRs can have both beneficial and harmful effects, they represent potential targets for early-stage treatment and vaccine development against SARS-CoV-2.